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The pH of the reaction mixture was gradually adjusted to the alkaline range (pH 1012) by the dropwise addition of 1 M NaOH solution, as alkaline conditions facilitate enhanced nucleation and stability of nanoparticles

doi:10.1007/s10753-019-01020-2 26

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Davis RE, Ruvolo V, Z-Q W, Ma W, Schober W, James Rolke J, Tidmarsh G, Andreeff M , Ruvolo PP

Efficacy and safety of Mirikizumab in a randomized Phase 2 study of patients with ulcerative colitis

The formation of RONS triggers inflammation, but on the other hand, inflammation also triggers the formation of RONS, which ends in oxidative stress, as described in Figure 2 (33)